Totgeburt durch Mundkeim Fusobakterium
Term Stillbirth Caused by Oral Fusobacterium nucleatum
Han, Yiping W. PhD; Fardini, Yann PhD; Chen, Casey
DDS, PhD; Iacampo, Karla G. MD; Peraino, Victoria A.; Shamonki, Jaime M. MD;
Redline, Raymond W. MD
Abstract
BACKGROUND: Intrauterine infection is a recognized cause of adverse pregnancy
outcome, but the source of infection is often undetermined. We report a case of
stillbirth caused by Fusobacterium nucleatum that originated in the
mother's mouth.
CASE: A woman with pregnancy-associated gingivitis experienced an upper
respiratory tract infection at term, followed by stillbirth a few days later. F.
nucleatum was isolated from the placenta and the fetus. Examination of
different microbial floras from the mother identified the same clone in her
subgingival plaque but not in the supragingival plaque, vagina, or rectum.
CONCLUSION: F. nucleatum may have translocated from the mother's
mouth to the uterus when the immune system was weakened during the respiratory
infection. This case sheds light on patient management for those with pregnancy-associated
gingivitis.
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