Effect of dental amalgam on cerebrum

Effect of dental amalgam on gene expression profiles in rat cerebrum,

cerebellum, liver and kidney

Takahashi Y, Tsuruta S, Honda A, Fujiwara Y,

Satoh M, Yasutake A.

Department of Dental Material Science, School of Dentistry, Aichi Gakuin

University, Aichi, Japan. yoshi@dpc.agu.ac.jp

J Toxicol Sci. 2012;37(3):663-6.

Abstract

Dental amalgam is a source of exposure to elemental mercury vapor in the

general population. The aim of this study was to elucidate the effect of

elemental mercury vapor exposure from dental amalgam restorations on gene

expression profiles. Out of 26,962 rat genes, mercury vapor was found to

increase the expression of 1 gene (Atp1b3) and decrease the expression of 1

gene (Tap1) in the cerebrum, increase the expression of 1 gene (Dnaja2) in

the cerebellum, increase the expression of 2 genes (Actb and Timm23) and

decrease the expression of 1 gene (Spink3) in the liver, increase the

expression of 2 genes (RT1-Bb and Mgat5) and decrease the expression of 6

genes (Tnfaip8, Rara, Slc2a4, Wdr12, Pias4 and Timm13) in the kidney.       

PMID: 22688007  [PubMed - indexed for MEDLINE]