Orofacial granulomatosis associated with hypersensitivity to dental amalgam.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Sep;112(3):335-41.

Orofacial granulomatosis associated with hypersensitivity to dental amalgam.

Tomka M <http://www.ncbi.nlm.nih.gov/pubmed?term=Tomka%20M%5BAuthor%5D&cauthor=true&cauthor_uid=21684771> , Machovcová A <http://www.ncbi.nlm.nih.gov/pubmed?term=Machovcov%C3%A1%20A%5BAuthor%5D&cauthor=true&cauthor_uid=21684771> , Pelclová D <http://www.ncbi.nlm.nih.gov/pubmed?term=Pelclov%C3%A1%20D%5BAuthor%5D&cauthor=true&cauthor_uid=21684771> , Petanová J <http://www.ncbi.nlm.nih.gov/pubmed?term=Petanov%C3%A1%20J%5BAuthor%5D&cauthor=true&cauthor_uid=21684771> , Arenbergerová M <http://www.ncbi.nlm.nih.gov/pubmed?term=Arenbergerov%C3%A1%20M%5BAuthor%5D&cauthor=true&cauthor_uid=21684771> , Procházková J <http://www.ncbi.nlm.nih.gov/pubmed?term=Proch%C3%A1zkov%C3%A1%20J%5BAuthor%5D&cauthor=true&cauthor_uid=21684771> .

Institute of Dental Research, First Faculty of Medicine, Charles University and General University Hospital, Prague, Czech Republic. tomka@vus.cz

Abstract

Orofacial granulomatosis is a clinicopathologic entity characterized by chronic swelling of the lip and possible soft tissues in the orofacial region owing to granulomatous inflammation of unknown cause. We present 3 cases of orofacial granulomatosis associated with allergic contact dermatitis to dental materials. Previous treatment with corticosteroids did not have any therapeutic effect. Patch testing revealed a positive reaction to several allergens, including dental amalgam and mercury in 2 cases. A lymphocyte transformation test modified for metals was used to evaluate lymphocyte reactivity. After the removal of the suspected allergens, all patients experienced recovery within 1 month, with the exception of the lip swelling, which gradually subsided over several months.

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