Effect of dental amalgam on cerebrum
Effect of dental amalgam on gene expression profiles in rat cerebrum,
cerebellum, liver and kidney
Takahashi Y, Tsuruta S, Honda A, Fujiwara Y,
Satoh M, Yasutake A.
Department of Dental Material Science, School of Dentistry, Aichi Gakuin
University, Aichi, Japan. email@example.com
J Toxicol Sci. 2012;37(3):663-6.
Dental amalgam is a source of exposure to elemental mercury vapor in the
general population. The aim of this study was to elucidate the effect of
elemental mercury vapor exposure from dental amalgam restorations on gene
expression profiles. Out of 26,962 rat genes, mercury vapor was found to
increase the expression of 1 gene (Atp1b3) and decrease the expression of 1
gene (Tap1) in the cerebrum, increase the expression of 1 gene (Dnaja2) in
the cerebellum, increase the expression of 2 genes (Actb and Timm23) and
decrease the expression of 1 gene (Spink3) in the liver, increase the
expression of 2 genes (RT1-Bb and Mgat5) and decrease the expression of 6
genes (Tnfaip8, Rara, Slc2a4, Wdr12, Pias4 and Timm13) in the kidney.
PMID: 22688007 [PubMed - indexed for MEDLINE]